THE INFLUENCE OF THE DENTIFRICE WATER WITH LYSOZYME ON SOFT TISSUES OF THE ORAL CAVITY OF PATIENTS WITH ORAL LICHEN PLANUS TOGETHER WITH DENTAL PATHOLOGY

  • O.V. Yeliseyeva Kharkiv national medical university
  • I.I. Sokolova Kharkiv national medical university
Keywords: processes of lipid peroxidation, oral lichen planus, chronic generalized periodontitis, «Lizomukoid».

Abstract

Prevalence and severity of generalized parodontitis depend especially on the course of diseases affecting the oral mucosa and those ones which are characterized by involvement of the oral mucosa. These diseases include mainly lichen planus. The common pathogenic agent of generalized parodontitis and lichen planus as well as of combination of them is inflammation, as generalized parodontitis is inflammation of parardontium tissue characterized by destruction of periodontium and dental ligamentous apparatus of the alveolar bone and lichen planus is a chronic inflammatory disease of skin and oral mucosa. The purpose is to study processes of lipid peroxidation in the saliva of patients with lichen planus of the skin along with chronic generalized parodontitis.

The study involved three groups of patients:

Group 1was represented by patients with generalized parodontitis associated with typical form of lichen planus of skin (12 individuals).

Group 2 involved patients with chronic generalized parodontitis without comorbidities, lichen planus in particular (19 individuals).

Group 3 was represented by apparently healthy donors (control group) (19 individuals).

Complete examination of parodontium tissue was carried out for all patients. The parodontium condition was estimated on the basis of patients’ complaints, dental examination over time with assessment of basic hygienic and parodontal indices.

Unstimulated mixed saliva of patients and control group were used as the material for study of lipid peroxidation processes at organ level. In order to estimate level and character of free-radical oxidation 4 indices were applied: TBA-active products level, activity of catalase, superoxide scavenger and functional index of free-radical oxidation.

It has been established that in patients with chronic generalized parodontitis as well as in patients with chronic generalized parodontitis combined with lichen planus increased level of end products of lipid peroxidation processes is observed. However, in patients with lichen planus significantly (1.8 times as much) increased content of TBA-active products indicating more pronounced activation of processes of lipid peroxidation at organ level in these patients is observed. Activity of antioxidant defense enzymes in the saliva of patients is decreased. Dramatic changes are apparent in activity of SOD in patients of both groups under study. The obtained data showed the decreased resistance to peroxidation at organ level and can be considered as one of mechanisms of affecting of oral cavity tissues. The study that has been carried out proved influence of oxidative stress in pathogenesis of lichen planus and ground the necessity to use antioxidants and antihypoxants in complex therapy.

Taking the obtained data into consideration, complex therapy including systemic treatment of lichen planus and topical treatment of chronic generalized parodontitis was indicated to patients with combined course of lichen planus of typical form and chronic parodontitis of primary and mild degree.

The clinical study has made it possible to establish that complex of medical and preventive measures such as systemic treatment of lichen planus, advanced hygienic care of the oral cavity with the use of Lizomucoid mouthwash, Lacalut aktiv therapeutic toothpaste is rather effective for treatment of chronic generalized parodontitis associated with lichen planus of typical form.

Downloads

Download data is not yet available.

References

1. Ардаматский Н.А. Методика определения физиологического и патологического перекисного окисления / Ардаматский Н.А., Абакумова Ю.В., Корсунова Е.Н. // Экоген.- 1994. - №4. – С.9.

2. Баранник Н.Г. Красный плоский лишай слизистой оболочки полости рта. К вопросу об этиопатогенезе / Баранник Н.Г. // Вестник стоматологии. – 1995. – № 1. – С.14-17.

3. Гланц С. Медико-биологическая статистика / С. Гланц. - М.: Практика, 1999. - 459 с.

4. Гончаренко М.С. Метод оценки перекисного окисления липидов / М.С. Гончаренко, А.М. Латинова // Лабораторное дело.- 1985.- № 11.- С.60-61.

5. Грудянов А.И. Заболевания пародонта / А.И. Грудянов. - М.: Изд-во "Медицинское информационное агентство", 2009. - 336 с.

6. Довжанский С.И. Красный плоский лишай / С.И. Довжанский, Н.А. Слесаренко. - Саратов: Изд-во Саратовск. ун-та, 1990.- 176 с.

7. Казарина Л.Н. Опыт лечения больных КПЛ / Казарина Л.Н., Гажва С.И. // Казанский вестник стоматологии. - 1998. - №2. - С. 86.

8. Метод определения активности каталазы / [Королюк М.А., Иванова Л.И., Майорова И.Г., Токарев В.Е.] // Лабораторное дело.- 1988.- № 1.- С.16-18.

9. Костюк В. A. Простой и чувствительный метод определения супероксиддисмутазы, основанный на реакции окисления кверцетина / В.А. Костюк, А.И. Потапович, Ж.В. Ковалева // Вопросы медицинской химии.-1990.-Т. 3 6, № 2 . - С . 88-91.

10. Лукиных Л.М. Перекисное окисление липидов как одно из звеньев патогенеза красного плоского лишая слизистой оболочки полости рта / Лукиных Л.М., Тиунова Н.В. // Нижегородский медицинский журнал. -2008. - № 2, вып. 2. - С. 105-107.

11. Петрова Л.В. Клиника, патогенез и лечение красного плоского лишая слизистой оболочки полости рта: автореф. дис. на соискание науч. степени д-ра мед. наук: спец 14.01.22 «Стоматология» / Л.В. Петрова. – М., 2002. – 42 с.

12. Рабинович О.Ф. Методы диагностики и местного лечения заболеваний слизистой оболочки рта (красный плоский лишай, рецидивирующий афтозный стоматит, декубитальные язвы) / Рабинович О.Ф., Эпельдимова Е.Л. // Стоматология. - 2005. - № 3. - С. 58-63.

13. Свистунов І.В. Біохімічні показники у хворих на червоний плоский лишай: значення для діагностики, лікування та прогнозу / І.В. Свистунов // Український журнал дерматології, венерології, косметології. – 2004. – № 1. – С. 11 – 14.

14. Святенко Т.В. Червоний плоский лишай: діагностика та лікування / Т.В. Святенко. – Донецьк: Каштан, 2008.- 271 с.

15. Basic aspects and measurement of the antioxidant vitamins A and E / M. Marquez, C.E. Yepez, R. SutilNaranjo [et al.] // Invest. Clin. - 2002. - Vol.3.- P. 191- 204.

16. Esmaili N. Oral lichen planus: frequency and clinical feature / Esmaili N., Emami Rasavi H. // J. Eur. Acad.Dermatol.Venereol.- - 2003. – Vol. 17, Suppl.3. – P.286.

17. Findler M. Images in clinical medicine. Oral lichen planus as a clinical sign of graft-versus-host disease / M. Findler, A.A. Garfunkel // N. Engl. J. Med. 2003 - Vol. 349 , N 23 - P. 22-23.

18. Oral lesions in patients with lichen planus / Mihic L.L., Budimir J., Situm M. [et al.] // Acta clinica Croatica. – 2008. - №47(2).- P.91-6.

19. Rossi L. Clinical consideration and statistical analysis on 100 patient with oral lichen planus / Rossi L., Colonsanto S. // Minevra Stomatol. – 2000.- Vol. 49(9). - P.393-398.

20. Sugermann P.B. Oral lichen planus: cause, diagnosis and management / Sugermann P.B., Savage N.W. // Aust. Dent. J. – 2002. – Vol. 47. – P.290-297.
Published
2018-03-21
How to Cite
Yeliseyeva, O., & Sokolova, I. (2018). THE INFLUENCE OF THE DENTIFRICE WATER WITH LYSOZYME ON SOFT TISSUES OF THE ORAL CAVITY OF PATIENTS WITH ORAL LICHEN PLANUS TOGETHER WITH DENTAL PATHOLOGY. Ukrainian Dental Almanac, 2(1), 26-29. Retrieved from https://dental-almanac.org/index.php/journal/article/view/132
Section
THERAPEUTIC DENTISTRY