• O.V. Pavlenko Institute of Stomatology National Medical Academy of Postgraduate Education im. P.L.Shupyka
  • R.Yu. Bida Institute of Stomatology National Medical Academy of Postgraduate Education im. P.L.Shupyka
Keywords: plasma rich in platelets, regeneration, growth factors, dentistry.


The process of wound healing is often observed in injurys that occur in the body, can often vary between a clinic and manifestations, because today it remains questionable as to solve this problem. Modern medicine requires new treatments for this type of injury. One of them is the technology of plasma-rich platelets and growth factors. This type of biological treatment leads to natural tissue regeneration method by which you can optimize and reduce healing time. This is achieved through an array of proteins from plasma enriched with platelets, which are involved in the recovery of damaged tissues. Thus, their restoration is natural and involves removing dead cells, their proliferation and migration to the site of injury, where the formation of new vascular structures. The organization of these elements affects the healing process after damage, preventing loss of fibrous elements that cause the reduction of functional ability and reducing on the "volume of tissue. Growth factors play an important role in coordinating all processes of healing. This article reflects the relevant aspects of the application in medicine modern biological technology autoplazmy enriched with platelets. in recent years, marked a significant increase in interest for this biomaterial that caused high efficiency at a high level of safety and low cost. Nowadays, plasma rich in platelets actively used in surgery, dentistry, traumatology, orthopedics, cosmetic, etc. Autoaplazma enriched with platelets has several positive features, namely, speed up the regeneration of tissues, no anti-inflammatory effect, reducing pain. Growth factor is a naturally occurring substance capable of stimulating cellular growth, proliferation, healing, and cellular differentiation. Usually it is a protein or a steroid hormone. Growth factors are important for regulating a variety of cellular processes. Growth factors typically act as signaling molecules between cells. Examples are cytokines and hormones that bind to specific receptors on the surface of their target cells. They often promote cell differentiation and maturation, which varies between growth factors. For example, bone morphogenetic proteins stimulate bone cell differentiation, while fibroblast growth factors and vascular endothelial growth factors stimulate blood vessel differentiation (angiogenesis). PRGFEndoret contains a cocktail of autologous growth factors that proceed from both the plasma and the platelets. In fact, the platelets have a complex storage system in the form of intracellular granules that allow them to transport a large number of biologically active molecules. According to some authors, this list of proteins and peptides can come close to 500 molecules. Alpha (α) granules are the most abundant as there are around 40 to 80 alpha granules per platelet, but they are also the ones with the greatest retention capacity. In addition, they contain a series of antibacterial proteins that are generically called thrombocidines and which are lethal for a large variety of bacterial species.

The system of PRGF stands for Plasma Rich in Growth Factor. It is a technology developed to promote the regeneration, repair and healing of the injured and damaged tissues. In the article below, we have elaborated the methods of PRGF-Endoret application to patients suffering from injuries or damages to soft tissue in the maxillofacial area.


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How to Cite
Pavlenko, O., & Bida, R. (2018). THE ROLE OF PLASMA ENRICHED WITH PLATELETS AND GROWTH FACTORS IN MODERN MEDICAL PRACTICE. Ukrainian Dental Almanac, 2(1), 41-44. Retrieved from