THE CONTENT OF IMMUMOGLOBULINS IN THE ORAL LIQUID OF CHILDREN LIVING ON TERRITORY WITH DIFFERENT LEVELS OF POLLUTION

  • N.V. Malko Lviv National Medical University of Danylo Halytsky, Ukraine
  • E.V. Bezvushko Lviv National Medical University of Danylo Halytsky, Ukraine
  • G. V. Girchak Lviv National Medical University of Danylo Halytsky, Ukraine
Keywords: children, gingivitis, ecology, immunoglobulins.

Abstract

The influence of environment on general state of children today for anybody doesn’t cause a doubt. Studies testify that an increase level of radiation, pollution of environment heavy metals create the background risk for the rise of periodontal diseases.

The purpose of study is to determine the level of immunoglobulins A, M, G in the oral liquid of children with chronic catarrhal gingivitis, living on territory with different levels of pollution.

The material and research methods. The study of immunological state of the oral liquid was conducted in 120 children with chronic catarrhal gingivitis, living on ecologically polluted and iodine-, fluoride deficient territories of EPR (main group) and in 80 children with chronic catarrhal gingivitis, residents of ecologically clean region (comparison group). The control group consisted of 37 children with a healthy paradontium, living in ecologically clean region.

Results of the research and their discussion. As the result of conducted studies we found that with the increase of age of children with chronic catarrhal gingivitis (CCG) regardless of their residence the concentration of immunoglobulins in the oral liquid decreased (table 1). So, if in 7-years-old children who live in ecologically polluted region, the content of IgA in the oral liquid was 0.878±0.015 g/l, in 12-years-old children the concentration of IgA was reduced to 0.661±0.014 g/l (р1<0.01), reaching minimum values in 15-years-old adolescents − 0.467±0.015 g/l (р1<0.01).

In children with CCG, who live on ecologically clean territories, the concentration of IgA was reduced from

1.179±0.011 g/l in 7-years-old to 1.150±0.012 g/l in children aged 12 years (р1<0.05). The least values of the concentration of IgA were diagnosed in 15-years-old adolescents − 0.933±0.014 g/l (р1<0.01).

The content of immunoglobulin M in the oral liquid of children with chronic catarrhal gingivitis of main group decreased from 0.869±0.012 g/l in children aged 7 years to 0.725±0.011 g/l in 12-yers-old children (р1<0.01). It should be noted that in 15-years-old adolescents with CCG − residents of ecologically polluted region observed the lowest value of this indicator, that was 0.635±0.011 g/l (р1<0.01).

In children with chronic catarrhal gingivitis, who live in ECR, the decrease of the concentration of IgM in the

oral liquid was less pronounced. We investigated the content of IgM in the oral liquid was decreased from 1.110±0.010 g/l in 7-years-old children to 0.928±0.011 g/l (р1<0.01) in 12-years-old children. The minimum values of the content of IgM in the oral liquid were found in 15-years-old adolescents of comparison group − 0.855±0.011 g/l (р1<0.01).

The analysis of the concentration of IgG in the oral liquid of children, who live on territory with the high level

of pollution and iodine, fluoride deficit showed that the highest values of the content of IgG in the oral liquid were found out in 7-years-old children − 0.943±0.012 g/l. In further reduction of the concentration of IgG determined in 12-years-old children from 0.749±0.011 g/l (р1<0.01) to 0.676±0.010 g/l (р1<0.01) in 15-years-old adolescents of main group.

In children with CCG of comparison group the changes of the concentration of IgG in the oral liquid have the same character: the decrease of the concentration of IgG researched from 1.110±0.012 g/l in 7-years-old children to 0.973±0.010 g/l (р1<0.01) in 12-years-old children, with minimal values (0.855±0.012 g/l, р1<0.01) in 15-years-old adolescents of comparison group.

Conclusions. As the result of conducted studies we found that in children with chronic catarrhal gingivitis from both living regions the concentration of IgA, IgM, IgG reduced with the increase of age, thus in children from ecologically polluted territories the obtained values were lower than in children with CCG who did not experienced the negative influence of environment.

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References

1. Безвушко Е. В. Комплексна оцінка стоматологічного здоров’я та фізичного розвитку дітей, що проживають у регіоні з комбінованим впливом забруднення довкілля та дефіциту фтору і йоду / Е. В. Безвушко // Екологія та здоров’я. – 2010. – № 1. – С. 45–47.

2. Грузєва О. В. Проблеми здоров’я населення, пов’язані з екологічними чинниками / О. В. Грузєва // Науковий вісник НМУ ім. О.О. Богомольця. – 2007. – С. 67–68.

3. Захворюваність дитячого населення України та чинники, які впливають на здоров’я дітей / Н. Я. Панчишин, В. Л. Смірнова, О. Я. Галицька- Хархаліс // Актуальні питання педіатрії, акушерства та гінекології. – 2011. – № 2. – С. 131–132.

4. Климчук М. А. Стан навколишнього середовища та його вплив на здоров’я населення Львівської області / М. А. Климчук // Довкілля та здоров’я. – 2005. – № 3. – С. 43–45.

5. Лук’яненко Н. С. Дослідження частоти поліморфних локусів генів І та ІІ фаз біотрансформації ксенобіотиків у дітей з екопатологією, спричиненою солями важких металів та фтором / Н. С. Лук’яненко // Педіатрія, акушерство та гінекологія. – 2010. – № 5. – С. 44 – 48.

6. Посібник з лабораторної імунології / [Л.Є.Лаповець, Б.Д. Луцик, Г.Б. Лебедь, В.М. Акімова]. – Львів, 2008. – 187 с.

7. Alawi M. A. Concentrations of some heavy metals (Cd, Cu, Pb, Se and Sn) in human teeth at different ages and the correlation to caries / M. A. Alawi, A. Abusbaih // JJC. – 2010. – Vol. 5, № 2. – P. 191–199.

8. Atler A. Y. Immunologia / A. Y. Atler.– Wroclaw: WMUP, 2007.– 364 p.

9. Luchinskiy M. A. Health condition, molecular genetics and biochemical markers of individual sensitivity to xenobiotics in children / M. A. Luchinskiy // The Pharma Innovation Journal. – 2013. – Vol. 2, № 4. – P. 86–88.
Published
2018-03-21
How to Cite
Malko, N., Bezvushko, E., & Girchak, G. V. (2018). THE CONTENT OF IMMUMOGLOBULINS IN THE ORAL LIQUID OF CHILDREN LIVING ON TERRITORY WITH DIFFERENT LEVELS OF POLLUTION. Ukrainian Dental Almanac, 1(3), 95-99. Retrieved from https://dental-almanac.org/index.php/journal/article/view/185
Section
CHILDHOOD STOMATOLOGY