@article{Kashivska_Rozhko_Melnychuk_2018, title={THE CHANGES IN TOTAL PROTEIN LEVEL IN BLOOD SERUM AND ORAL FLUID OF THE PATIENTS DURING THE TREATMENT OF GENERALIZED PERIODONTITIS COMBINED WITH CHRONIC LIVER DISEASES}, url={https://dental-almanac.org/index.php/journal/article/view/69}, abstractNote={<p><strong>Introduction. </strong>Clinical medicine has numerous evidences for mutual complications of different diseases of internal organs associated with generalized periodontitis (GP). It is known that in patients with GP all kinds of metabolism are disturbed. It is not fully clarified how these changes occur during the combined pathology of periodontal and hepatobiliary system, and there are no elaborated methods of complex treatment of patients in such cases. Therefore, research in this direction remains actual.</p> <p><strong>Aim. </strong>The study of total protein (TP) content in blood serum and oral fluid of the patients with GP with and without concomitant liver pathology and its changes under the influence of complex treatment.</p> <p><strong>Methods. </strong>24 healthy and 110 patients with chronic GP of I degree were examined, among them: 34 – without liver pathology, 49 – with concomitant cryptogenic hepatitis (CH) and 27 – with concomitant subcompensated liver cirrhosis (SLC). The level of TP in blood serum and oral fluid was determined. There were selected 19 patients with GP without concomitant pathology and 29 patients with GP combined with CH. It included initial periodontal therapy, local treatment using Stomatofit liquid, mixture of Glutargin and Atoxil and general therapy using medications Glutargin and Calcemin.</p> <p><strong>Results. </strong>In patients with GP without and with concomitant CH and SLC the level of TP in blood serum significantly reduced (on 4,39%, 11,12% and 15,07%), and in oral fluid – increased (in 1,48, 2,70, і 3,47 times). After the treatment the content of TP in blood serum increased in the case of GP, achieving the data of healthy people, and with GP on the background of CH – on 7,73% (р<sub>1</sub>&lt;0,001); in oral fluid it reduced in 1,15 (р<sub>1</sub>&gt;0,05) and 1,85% (р<sub>1</sub>&lt;0,001) times accordingly.</p> <p>The decrease of TP level in blood serum of patients with GP without concomitant pathology may indicate the deceleration of protein-synthesizing liver function and in combination of GP and chronic liver diseases the significant hypoproteinemia may indicate the decrease of hepatocytes which are replaced by connective tissue. The increase of TP level in blood serum probably is due to the strengthening of catabolic processes in periodontal and the weakening of biosynthesis of its organic base including collagen. The increasing of TP level in blood serum of patients with GP after the complex treatment apparently is due to the influence of the applied hepatoprotector Glutargin which contributed to the restoration of the protein-synthesizing liver function.</p> <p><strong>Conclusion. </strong>Multidirectional changes of TP level in biological fluids were detected in patients with GP. In blood serum this indicator significantly increased and in oral fluid – reduced in all examined groups (р<sub>1</sub>&lt;0,005; р<sub>1</sub>&lt;0,001). Under the influence of the combined treatment of patients with GP without and with concomitant CH the protein metabolism normalized, which manifested by significant increase of the TP level in blood serum in all patients (р<sub>1</sub>&lt;0,01; р<sub>1</sub>&lt;0,001),the tendency of its reducing in oral fluid during GP (р<sub>1</sub>&gt;0,05) and reliable decreasing - in the case of GP combined with CH (р<sub>1</sub>&lt;0,001).</p&gt;}, number={5}, journal={Ukrainian Dental Almanac}, author={Kashivska, R.S. and RozhkoМ.М. and MelnychukG.М.}, year={2018}, month={Mar.}, pages={14-17} }