THE CHANGES IN TOTAL PROTEIN LEVEL IN BLOOD SERUM AND ORAL FLUID OF THE PATIENTS DURING THE TREATMENT OF GENERALIZED PERIODONTITIS COMBINED WITH CHRONIC LIVER DISEASES

  • R.S. Kashivska State Higher Educational Institution «Ivano-Frankivsk National Medical University»
  • М.М. Rozhko State Higher Educational Institution «Ivano-Frankivsk National Medical University»
  • G.М. Melnychuk State Higher Educational Institution «Ivano-Frankivsk National Medical University»
Keywords: generalized periodontitis, cryptogenic hepatitis, subcompensated liver cirrhosis, total protein, biological fluids, combined treatment.

Abstract

Introduction. Clinical medicine has numerous evidences for mutual complications of different diseases of internal organs associated with generalized periodontitis (GP). It is known that in patients with GP all kinds of metabolism are disturbed. It is not fully clarified how these changes occur during the combined pathology of periodontal and hepatobiliary system, and there are no elaborated methods of complex treatment of patients in such cases. Therefore, research in this direction remains actual.

Aim. The study of total protein (TP) content in blood serum and oral fluid of the patients with GP with and without concomitant liver pathology and its changes under the influence of complex treatment.

Methods. 24 healthy and 110 patients with chronic GP of I degree were examined, among them: 34 – without liver pathology, 49 – with concomitant cryptogenic hepatitis (CH) and 27 – with concomitant subcompensated liver cirrhosis (SLC). The level of TP in blood serum and oral fluid was determined. There were selected 19 patients with GP without concomitant pathology and 29 patients with GP combined with CH. It included initial periodontal therapy, local treatment using Stomatofit liquid, mixture of Glutargin and Atoxil and general therapy using medications Glutargin and Calcemin.

Results. In patients with GP without and with concomitant CH and SLC the level of TP in blood serum significantly reduced (on 4,39%, 11,12% and 15,07%), and in oral fluid – increased (in 1,48, 2,70, і 3,47 times). After the treatment the content of TP in blood serum increased in the case of GP, achieving the data of healthy people, and with GP on the background of CH – on 7,73% (р1<0,001); in oral fluid it reduced in 1,15 (р1>0,05) and 1,85% (р1<0,001) times accordingly.

The decrease of TP level in blood serum of patients with GP without concomitant pathology may indicate the deceleration of protein-synthesizing liver function and in combination of GP and chronic liver diseases the significant hypoproteinemia may indicate the decrease of hepatocytes which are replaced by connective tissue. The increase of TP level in blood serum probably is due to the strengthening of catabolic processes in periodontal and the weakening of biosynthesis of its organic base including collagen. The increasing of TP level in blood serum of patients with GP after the complex treatment apparently is due to the influence of the applied hepatoprotector Glutargin which contributed to the restoration of the protein-synthesizing liver function.

Conclusion. Multidirectional changes of TP level in biological fluids were detected in patients with GP. In blood serum this indicator significantly increased and in oral fluid – reduced in all examined groups (р1<0,005; р1<0,001). Under the influence of the combined treatment of patients with GP without and with concomitant CH the protein metabolism normalized, which manifested by significant increase of the TP level in blood serum in all patients (р1<0,01; р1<0,001),the tendency of its reducing in oral fluid during GP (р1>0,05) and reliable decreasing - in the case of GP combined with CH (р1<0,001).

Downloads

Download data is not yet available.

References

1. Зв’язок захворювань пародонта із загальносоматичною патологією / [О.М. Немеш, З.М. Гонта, І.В. Шилівський, А.П. Скалат] // Новини стоматології. – 2006. – №2(47). – С. 34-37.
2. Связь заболеваний внутренних органов с воспалительными поражениями полости рта / [И.А. Горбачева, Л.Ю. Орехова, Л.А. Шестакова, О.В. Михайлова] // Пародонтология. – 2009. – №3. – С. 3-6.
3. Болезни пародонта. Патогенез, диагностика, лечение / [А.С. Григорьян, А.И. Грудянов, И.А. Рабухина, О.А. Фролова]. – М.: Мед. информ. агентство, 2004. – 320 с.
4. Горбачева И.А. Единство системних патогенетических механизмов заболеваний внутренних органов, связанных с генерализованным пародонтитом / И.А. Горбачева, А.И. Кирсанов, Л.Ю. Орехова // Стоматология. – 2004. – Т.83, №3. – С. 6-11.
5. Интегрированный подход в диагностике и лечении хронического генерализованного пародонтита и хеликобактериальной инфекции / [А.М. Ковалевский, А.К. Иорданишвили, Ю.А. Грухин, Я.Я. Мазурова] // Пародонтология. – 2012. – №4 (65). – С. 85-87.
6. Борисенко А.В. Нарушение белкового обмена в тканях пародонта при патологии и их коррекция в комплексном лечении: автореф. дис. на соискание науч. степени доктора мед. наук: спец. 14.00.21 „Стоматология” / А.В. Борисенко. – К., 1992. – 28 с.
7. Лабораторные методы исследования в клинике: [справочник] ; под ред. В.В. Меньшикова. ? М.: Медицина, 1987. – С. 174-175.
8. Рациональная диагностика и фармакотерапия заболеваний органов пищеварения : [справочник „VADEMECUM Доктор Гастроэнтеролог”] ; под ред. проф. О.Я. Бабака, Н.В. Харченко. – К.: ООО „ОИРА Здоров’я України”, 2005. – 320 с.
9. Дубоссарская Ю.А. Патология гепатобилиарной системы в практике гинеколога / Ю.А. Дубоссарская // Медицинские аспекты здоровья женщины. ? 2010. – № 3. ? С.12-19.
10. Мельничук А.С. Деякі показники білкового і кісткового обміну у хворих на генералізований пародонтит при частковій утраті зубів / А.С. Мельничук, М.М. Рожко, Г.М. Ерстенюк // Современная стоматология. – 2012. – №4. – С 24-26.
11. Ткаченко А.Г. Особливості клінічного перебігу, лікування та профілактики генералізованого пародонтиту у осіб молодого віку 18-25 років: автореф. дис. на здобуття наук. ступеня канд. мед. наук: спец. 14.01.22 „Стоматологія” / А.Г. Ткаченко. – К., 2006. – 20 с.
12. Мащенко И.С. Клинические, биохимические и иммунологические аспекты возникновения начальной степени генерализованного пародонтита / И.С. Мащенко, Ю.В. Чернова, Ю.И. Чарун // Вісник стоматології. – 2001. – №3. – С. 8-10.
13. Бабак О.Я. Глутаргин – фармакологическое действие и клиническое применение: [монография] / О.Я. Бабак, М.В. Фролов, Н.В. Харченко.- Харьков-Луганск: Элтон-2, 2005. – 456 с.
Published
2018-03-21
How to Cite
Kashivska, R., RozhkoМ., & Melnychuk, G. (2018). THE CHANGES IN TOTAL PROTEIN LEVEL IN BLOOD SERUM AND ORAL FLUID OF THE PATIENTS DURING THE TREATMENT OF GENERALIZED PERIODONTITIS COMBINED WITH CHRONIC LIVER DISEASES. Ukrainian Dental Almanac, (5), 14-17. Retrieved from https://dental-almanac.org/index.php/journal/article/view/69
Section
THERAPEUTIC DENTISTRY